Enzymes and Viruses
last updated 5.1.06

see Results of Two Studies with Enzymes and Viruses
see MCT, Lauricidin, and Monolaurin
see Antiviral/antimicrobial Components in Dairy
see Enzymes and Warts


Effect of Enzymes on Viruses

This link gives a nice basic description of viruses and how they work (the discussion continues over several pages, with pictures):
How Stuff Works: Virus
www.sirinet.net/~jgjohnso/ aboutviruses.html

Viruses are not technically living things. They are particles made of proteins and DNA or RNA. When talking about viruses, you will see virus treatments referring to viral deactivation, virus inactivation, virus control, and virus suppression as well as 'killing a virus'. All refer to trying to get rid of or stop the harmful spread and effects of virus infection. A reference to virus 'die-off' means what happens while trying to get rid of a virus problem. But this is not in the same literally meaning as bacteria or yeast die-off.

Digestive enzymes have excellent history in the treatment of viral diseases. Viruses may enter the body by a variety of paths. An invading virus should be subdued and immobilized by the immune system, lying dormant and harmless in the body. In the gut, certain agents of the immune system in the mucosa lining usually conquer any viruses. However, if the intestinal mucosa is damaged or is deficient this can leave an opening for a virus to be reactivated, get out of control and become industrious in the gut, even spreading to other parts of the body. The same doorway results from having a weakened immune system.

What happens now? The viruses may cause direct symptoms and complications. Possibly the virus leads to some gastrointestinal and/or neurological problems. This may force the immune system to work at a higher level constantly. It becomes overburdened on a daily basis, yet cannot completely destroy or subdue the virus. Viruses may include the stealth virus, herpes virus, measles, chicken pox, viral encephalitis among others. Some of these may cause autism-like symptoms in children. Remember, the pervasive developmental disorders are only diagnosed by observable behaviors and not on any specific physiological testing. There are a multitude of biochemical situations that could lead to these expressed behaviors. There is evidence that viruses can cause dysfunction in the brain and damage the protective coating, called myelin, around the nerves. This leaves the nerves exposed and susceptible to damage. Viruses are suspect as agents in many autoimmune diseases.
see Autoimmune/Neurological Conditions
see PDD/autism
see Leaky Gut

So what do you do about a virus once it becomes a problem? A basic therapy against such viruses needs to focus on the immune system: improving its ability to function, strengthening it, and enabling it to work at a more typical rate and manner. Some people are seeing improvements with particular antiviral medications. However, because of the nature of viruses, this may be more of a cross-your-fingers-and-hope-for-the-best therapy. Researchers are working to improve this as best they can.

Enzymes, particularly the proteases, turn out to be an excellent therapy to use against a virus, working on several levels. Many viruses are surrounded by a protective protein film, something a protease enzyme can digest away. Eliminating this coating leaves the viruses unprotected and vulnerable to antivirals and destruction.

Is there any evidence that enzymes are effective in the treatment of viruses? In 1995, Dr Billigmann published the results of a study with enzyme therapy as an alternative in the treatment of the virus Herpes zoster. In a controlled study with 192 patients, one of the objectives was to confirm that enzyme therapy had been effective with this virus in a previous study. The other objective was to compare the effectiveness of enzymes with that of a standard drug called acyclovir. The high costs of treatment with this drug and others often meant that Herpes zoster patients would not receive medicinal therapy. They concluded that overall the enzyme preparation showed identical efficacy with the drug acyclovir, and thus also confirming the results of the prior study. The Herpes zoster virus has been successfully dealt with since 1968 with enzymes. Enzymes are considered one of the best therapies with very few side-effects while also providing significant pain relief for the patient (Bartsch 1974; Scheef 1987). Bartsch eventually felt it was unethical to treat patients with viral conditions with anything other than enzyme therapy because the enzymes proved far superior as a treatment.

In addition, there is research and successful experience gained in the field of treating HIV, another viral-based condition. The Medical Enzyme Research Institute has published the following conclusions regarding the results of controlled studies underway from 1985 to 1994. First, they found that enzyme therapy significantly limits the progression of the early stages of HIV disease and the patients’ symptoms improve appreciably. Next, with people who are HIV positive, enzyme treatment can delay the onset of disease symptoms and, in some cases this delay continues indefinitely. Then, the appearance of infectious disease, and possible malignant disease, has become less common than in the control groups. Lopez (1994) gives a complete description of how enzymes assist with HIV/AIDS conditions, how they interact with the immune complexes and other factors in the disease, and scientific references.

Several other studies showed that enzyme therapy resulted in less symptoms, slower progression of the HIV viral infection, and greater improvement in the patient’s condition than either controls or groups receiving other standard drug therapy, such as AZT, at times by a significant margin.

Another discussion at the following link (scroll about half-way down the page)
Understanding the Viral Problem

The Effects of Plant Form Protease’s on Viruses
4 page download including pictures

The following link is from the Enzymedica site (a leading company in enzyme formulations and uses in health). They have a really nice 4 page discussion on how enzymes fight viruses. This is similar to how enzymes interact with bacteria, yeast, tumors, fibrin, and other gunk in the body we don't want there. Includes close-up micrograph photos of cells and illustrations. There are many references at the end as well.

http://www.enzymedica.com/pdf/ProteasesandViruses.PDF

Alpha-2-macroglobulin Function

Proteases and antiproteases in health and disease a review:
Alpha-2-macroglobulin
Note: The information on enzymes and viruses contained in this site and the tests conducted were developed independently of any product manufacturer. Volunteers contributed experiences and guidelines developed from there. This is not medical advise nor is meant to replace any medical therapy you are currently undergoing or considering.

An information trial was done with 20 volunteers who didn't know what enzyme product they were testing, just that it was a protease. All the participants had known virus problems and just about everyone had test results showing a specific virus.

Everyone was sent unmarked enzyme capsules and did not know what they were getting. This was so the testing could be more objective. They were told it was a protease product with no fillers or fruity enzymes, so that wouldn't be an issue. In fact, I just opened off the shelf bottles and poured the enzymes from the bottle directly into a ziplock bag and sent them...so these were not even something special from the manufacturer. The participants were told they didn't need to change anything they were currently doing. If they were already taking enzymes, just add these new ones between meals on top of your regular supplement schedule.

The idea was to see if these additional enzymes might help in a different way, or over and above, enzymes for digestion. It was a very basic evaluation we were shooting for. Participants sent histories of the person getting the enzymes and told to include any
changes at all they observed even if they weren't sure what the cause was.

In general, the results showed the enzyme product, which was Purify by Enzymedica, showed noticeable improvements for just about everyone.

Now, here are some of the things that came up and to keep in mind. It is worthwhile to pursue this because the preliminary trial showed results significant enough for consideration.

1. The test group was around 20 people (a couple haven't put in results and might not be included in the final analysis). Participants included mostly children and some adults. Most of the children had an autism spectrum diagnosis and everyone did have virus problems.

2. I wanted to see if some viruses responded better to the Purify proteases than others. However, because the list of viruses of the participants was so varied, the sample size of any particular virus was not high enough to say `this virus responded well and that one didn't'. This would be a nice thing to test in the future though. I know some studies get a lot of attention even if they only include 1, 3, or a dozen people, but that isn't enough to get a definite conclusion.

3. The number of participants in any particular age group was not high enough to definitely say `this age responds wonderfully but that one doesn't'. There were individuals in each age group that did respond well though. People tested from 1 month to 2 months in this trial depending on if they wanted to and what else was going on in their life.

4. Previous enzyme use didn't appear to make any difference. One person had been on a 3 capsules of enzymes at all meals regularly for over a year and saw improvement. Another person had never taken enzymes regularly and saw improvement. Most participants had used enzymes fairly regularly for awhile. Keep in mind that these are two different reasons for taking enzymes and selecting different enzyme formulations. This trial was not about food digestion. It was specific for systemic use of certain enzymes on viruses, although there is some cross-over between the two areas.

5. Question to be considered: Would any strong protease product produce such good results (Peptizyde, Wobenzym, etc) or is it just the particular blend in Purify? (just as Peptizyde can be used instead of GFCF for most but `copy-cat' products of Peptizyde have not been effective enough to do this).

6. Wobenzym has clinical testing on some of their products and various viruses. This does show that digestive enzymes can help with viruses, and in particular, at least of the ingredients or particular proteases in Wobenzym products are effective on viruses.
see Enzymes and Virus Research for some studies

7. One of the objectives was to see if higher doses of enzymes would be more effective than lower doses. 'Higher doses' was meant to be more than the 3-4 protease capsules typically given of 'good' brands of enzymes for food digestion. Participants were encouraged to shoot for 20 capsules a day. To put this in perspective, people with fibromyalgia or cancer may take as many as 45-90 capsules a day...or more! So 20 capsules was still much lower as a therapeutic dose.

In our trial, higher doses of 9-15 capsules seemed to make a bigger difference than just a few capsules throughout the day. Some people saw improvement from the very beginning with just a few capsules while others did not see improvement until they reached 9-12 capsules a day. Then the effectiveness was noticeable. This dose is over and above any enzymes taken for food digestion (if the person was taking enzymes for food digestion). Either pattern is possible.

8. Question to be considered: Are proteases more effective when used with other anti-viral products or treatments rather than used alone for viruses? This was not an objective of this trial. Some of the test participants had been doing other measures to treat for viruses. Others had not. My guess would be that anti-viral enzymes would be more effective when used with other anti-viral measures because both bacteria and yeast problems have responded this way. Proteases given with an anti-biotic or anti-fungal made the entire treatment more effective than just doing the protease or anti-biotic or anti-fungal alone. I would think there would be a similar synergistic effect with viruses. An anti-viral product could be something over-the-counter like monolaurin or a prescription med. And any other viral control measures available would also likely work toward the common goal of improving health against viral infection.

9. Question to be considered: What is the effect of having papain or bromelain or any other fruit derived enzyme in the product? Papain and bromelain are known to have properties different than the microbe derived proteases so having them in the mix might produce even better results or worse results…or maybe it doesn't even matter. The fruit derived enzymes are a particular sensitivity to some people so it would be a good point to find out.

10. I asked the people who know the technical side of their products at Enzymedica why they felt Purify was more effective on viruses? Was it a special enzyme in the mix? Was it any strong protease product would do and this just happened to be theirs? Would any other protease product produce similar effects? Why do they put `Virastop Formulation' on the Purify label to point out virus action and not bacteria or yeast action? Basically, where did this idea that Purify helps with viruses in particular come from and what is it based on?

The answer was that the science on proteases, in general, strongly supports virus control in many clinical studies. This is a known ability of digestive enzyme proteases.

Enzymedica makes more than one strong protease product. They have several. After thousands and thousands of people were using their products for all sorts of things, it kept coming up that the Purify was significantly better on cases of viral problems.

After time after time after time of people continually saying " WOW, this product was AWESOME for helping my virus problem," the company started really looking at it more closely. They were getting consistent feedback which in general was saying, `yea, Purify helped with bacteria and with yeast when I put it in my yeast treatment or detox overall but it TOTALLY ROCKS on my virus problem! I haven't had such relief in YEARS." This came up over and over and over.

This reminded me greatly of how Peptizyde was found to be effective for leaving a GFCF diet. Or how No-Fenol was found to be killer on yeast particularly when used with some kind of anti-yeast product. And how many of the other really useful guidelines used in enzymes and other supplements came about.

In this case, there does not seem to be any one particular item to point out. The proteases in Purify are a blend and not one particular protease or activity.


Enzymes and Virus: Interesting form of activity

A very interesting part of digestive enzyme action particularly with viruses is in the research literature. At first, the research and discussions seemed to say that sometimes proteases were helpful and sometimes they weren't.

But what was going on is that sometimes a study or discussion would be talking about proteases meaning from the added digestive enzymes, and sometimes they were referring to the proteases the viruses themselves produce (I will call these virus-proteases to help keep it straight). Viruses, bacteria, and yeast also make proteases to tear into our bodies.

So if you are reading in this area, remember to look to see if the proteases under discussion are referring to the ones from the enzyme supplement (the beneficial proteases) or if they are the ones produced by the viruses (the harmful proteases). Our bodies produce some enzyme inhibitors anyway. De-activating harmful proteases is one of the ways our bodies deal with pathogens and things going wrong in the body.

I noticed this in particular on articles and studies concerning HIV virus. One of the common treatments for HIV is to give a `protease inhibitor.' This is a compound designed to inhibit or de-active the proteases from the HIV virus. Not referring to proteases produced in your gut or from supplements. Proteases are very specific. So an inhibitor that de-actives a harmful protease from a virus may not have any effect on any other protease in the body. It gets a little confusing at time but it is a very important distinction. Reminds me of the concept that bacteria can be beneficial or harmful. So think of protease discussions similarly especially when reading about pathogens.

Proteases (the beneficial digestive enzyme kind) can enter the blood stream and go about doing useful work. One of the ways they can act is to be preferentially connected to a component of the immune system called Alpha-2-macroglobulin (I will write it as A2M for short). The digestive enzyme protease and the A2M have an attraction for each other.

The protease connects to the A2M molecule and the A2M wraps around it and protects it from being indiscriminately deactivated. The way this attachment between the A2M and the beneficial protease works is that the protease connects to a point in the A2M molecule just as it is attracted to any other substrate it can function on. But instead of breaking down the A2M molecule (digesting it), this action `springs the trap' and the protease enzyme is caught. When the protease `bites' the A2M molecule, the configuration of the A2M is physically changed, and A2M wraps around the protease. It sounds similar to an animal going for bait, springing a trap, and having a cage fall down on it.

In this cage, the beneficial enzyme is still functional. The protease is protected by the A2M yet still retains its activity. Similar to a caged animal still being very much able to eat, make noise, roam around and be active, yet it cannot escape nor can other animals get to it to harm or destroy it.

In addition, the A2M molecule appears to shuttle the beneficial protease to any part in the body that requires it. A2M sort of whisks the protease away to a site in the body that needs healing or is under attack. Similar to an emergency breaking out, an ambulance is told to get any medical people they can find, goes to the houses and places where there are medical people, and once the people get in, the ambulance speeds them off to wherever they are needed. Then the medical people go to work.

Research shows that when the protease connects to the A2M molecule, the A2M is switched from a 'slow' form to a 'fast' form. The fast form quickly mops up various compounds shown to be hazardous to health and disposes of them appropriately. This takes the harmful compounds out of circulation. [see selected studies 1,2,3,4 at
http://www.enzymestuff.com/discussionimmunesystem.htm]

So the beneficial protease becomes part of the immune system to work with it and facilitate function. Viruses consist of proteins and have protein coats. Since the protease does not lose activity when combined with the A2M it can still be effective. Many of the measures or medications used for auto-immune conditions aim to suppress the immune system because it is the immune system that is attacking the body. However, suppressing the immune system leaves the person open to more infections and problems as well as not fighting off the virus. Because proteases do not stimulate the immune system, protease can be used safely by those with auto-immune disorders.

The following link contains an in-depth description of A2M function in human health including references.
Alpha-2-macroglobulin

You might also want to read over some of the discussions on the multiple ways enzymes help in human health and support the immune system (incorporated in the following sections):
http://www.enzymestuff.com/conditioncancer.htm
http://www.enzymestuff.com/conditionautoimmune.htm
(the serrapeptidase info here is interesting)


Virus Symptoms: Cycling Patterns

One pattern that came up during this was the stair-step pattern of taking a dose of the Purify and seeing improvement for a few days and then see it wane, then upping the dose by a capsule or two and seeing more improvement for a few days and then seeing it wane. Then upping the dose again and seeing more improvement and then again it wanes. The overall level of improvement stayed above the starting point. I asked about this stair-step pattern. It was immediately explained to me that this is the pattern of viral action because it follows the pattern of viral growth and activity. This is what to expect when it is working.

Viruses are elements that infect a cell. They are not true living organisms that are self-sustaining. They insert their DNA or RNA and replicate inside the cell making many more copies of itself using the cell's resources. This replication can happen in a short time or over a long period of time. The virus may even hibernate or hide-out quietly in a cell for a pro-longed time (over many many years). At some point, the cell is burst opened, the cell is killed, and all the virus copies are free to go out and infect other cells. And the cycle continues.

Viruses can show a cycling of illness followed by improvement. I remember that several times in the past on various message boards, a parent would say their child would be really good for about 6 weeks at a time then be really down and ill for no apparent reason. Then the child would just get better for another period of 6 weeks. And this cycle would go on and on. Several people would reply that this can indicate a virus. The period might not be 6 weeks, but 3 months, 4 months, 6 months at a time. It was just the repeating pattern with no apparent reason of getting ill or getting better that stood out. In some information on malaria, it mentions `fever that goes in cycles' as a symptom and goes on to say that a prime natural alternative in the prevention and treatment of malaria is proteolytic enzymes.

"Proteolytic enzymes are valuable in the case of malaria, because the invading parasite is a protein. Through the proteolytic activity of the digestive proteases they will find the parasite and kill it. Enzymes, even though they are proteins, are able to pass through
the digestive juices, transit the digestive tract, be absorbed into the blood stream, coat themselves with an alpha 2 macroglobuline produced by the host to avoid eliciting an immune response by the host fagocites and then, finally, arrive to the site where they are needed crossing every barrier, with what would appear as just 'instinct'."

http://www.subud-health.org/page37-malariaindepth.html

The cycling pattern is there due to the cycling nature of virus growth (infect a cell for some time, explodes out in mass, infects more cells, latent period while virus grows inside of cells, burst out in mass, and so on).

The recommended pattern of dosing enzymes is to keep increasing the enzymes until this cycling stair-step pattern stabilizes. At that point continue the current dose of enzymes for about 3 weeks. Then decrease the enzymes. The improvements should continue. If a point is reached where there is regression, then continue the enzymes at a slightly higher dose for a week or so, and then try to decrease enzymes again.

Other Possible Viral 'Die-off' Effects or Side-effects can be:

- a fever or pains that run in cycles - very characteristic of viruses because of how they multiply. The virus infects a cell, multiplies internally where there wouldn't be any external disruption. Then after some time, the virus bursts out of the cell releasing many more copies of the virus. The cycle time can be a period of days, weeks, or even months.

- a very localized rash on different parts of the body; this may show up right away or after a week or two of treatment - particularly if you work up to higher doses that begin seriously impacting the virus. The virus may harbor inside nerve cells within the body. When activate or being 'killed', the virus travels along the nervous system until it reaches the 'surface' of your body, or the skin layer. At that point, it can cause a painful rash. This is often at one spot or one side on the upper arms, torso, neck or face.

- muscle or joint pain - your son might not be able to say he has this. If you can communicate the question to him, see if he has this. Teeth grinding might be a way to deal with discomfort. If there is a 'viral rash', the rash might even go away but the muscle or joint pain can linger past that. With a child, keep this in mind when treating a virus because he may be having physical pains and can't express it. The child might be extra fussy, resist physical activities, or have outbursts that are different than before.


My Experience with Purify (now called ViraStop)

I had some left over test enzymes and so decided to take them myself at higher doses. I did not think I had a virus nor have I been feeling bad, so I just wanted to try higher doses of proteases.

I took 50 capsules a day. 10 at a time, 5 times a day between meals. Other people using enzymes for fibromyalgia or cancer were taking 45-90 capsules a day of proteases so I wasn't usually high for therapeutic use.

Shortly after, about 48 hours later, I had a really painful rash on the top of my right shoulder. My entire right arm HURT. It wasn't just an ouchy surface pain at the skin level. I mean it really HURT completely to the bone, much like I had seriously pulled every muscle all down my arm. I could hardly lift a fork without it hurting. It was really odd. I didn't connect this to the enzymes right away because I didn't think I had a virus. And I wasn't hurting or in discomfort in any other way - no headaches, stomachache, unusual fatigue.

I stopped the enzymes because I didn't want to mess up my high dose experiment and thought that after a few days the rash would go away and I would try again. I thought maybe I had been exposed to poison ivy or poison oak somehow.

The rash and pain stayed all week. Didn't get one bit better even though I tried an array of topical creams that were supposed to help. It also didn't spread and get worse (which is very usual for typical skin rashes like poison ivy/oak). So then I thought about the enzymes and started them again (at 50 capsules a day). The rash started to go away quicker and the pain lessened by half in about 3-4 days.

So then I stopped the enzymes to see if the rash would just finally go away on its own (I was still not convinced it was viral). The rash didn't get any better on its own for another week. It stayed at the very same level. After a week, I started the enzymes again (at 50 capsules a day), and then the rash healed up completely. A mild lingering pain persisted for another 2 weeks before finally going away.

When researching this, I found out this is typical of how a virus or anti-viral works. The virus gets into certain nerves and when it is treated, whereever that nerve `connects' to the skin surface can develop a rash. The nerves under attack also cause pain in the part of the body they connect to. So you don't get an overall body rash or pain. You get highly localized pains or just on one side of the body (one side of face, or one arm, or one leg, etc). The joint or muscle pain lingers longer than the surface rash. Or you might just have milder muscle pain and no rash.

I was inadvertantly hitting some virus really hard, but if you start with much lower doses of enzymes (Purify) the reaction would be not be that severe.

I still have little dot scars-marks on my shoulder. I don't know what virus it might have been...perhaps some latent cold sore virus or flu virus from long ago.

Reye's Syndrome Caution

Reye's syndrome is a condition that can appear after a viral infection, particular if aspirin/salicylate was taken during the virus infection. It is a rare but serious illness that hits teenagers and children, and has a particular pattern of symptoms.

http://www.thearc.org/faqs/reyes.html

Research

Enzymes and Viruses
click link for studies

A compound called MCT, Lauricidin, or monolaurin and found in coconut oil, mother's milk, and diary is effective in killing viruses. Thanks to several parents reporting a decrease in hearing sensitivity with Houston enzymes containing MCT . . and some other parents reporting with specific details, some new information on MCT has come up. Viruses can be hard to treat. Enzymes can be effective. The following compounds can also be effective. Combined together digestive enzymes and these compounds might work together very synergistically and be effective in a viral treatment program.

see MCT, Lauricidin, and Monolaurin
see Antiviral/antimicrobial Components in Dairy

Descriptions of Specific Viruses
links to other sites with detailed descriptions on various viruses

see Plantar Warts - includes images

Participating in a Trial Run of Enzymes with Viruses
Note: All trials are completed at this time. Any further effort will be posted but none are anticipated until at least spring 2006.

If you are interested in participating in an informal study trial of enzymes on specific viral conditions, and meet the following requirement, please email here:

  • already take good quality digestive enzymes for food digestion. This is so any possible improvements will not be confused with the improvement commonly seen with improved digestion of food
  • have a known virus of any type
  • can allow 1-3 months to try this
  • you do not need to be on anyaa particular diet or nutritional plan
  • all materials are supplied (no overall cost for participating)

Additional information on enzymes with viruses


At times, the parent (or caregiver...don't want to leave out any of the totally awesome grandparents or therapists here!) says that when the child get a fever or become ill, they are 'less autistic' during that time...meaning that many of the negative behaviors go away. Maybe the child starts talking and interacting more. This 'improvement' goes away when the fever goes away. Does this happen in your case?

Viruses are both a bane and fascination in biology. This is one area where agriculture experience is less than helpful. If a crop gets a virus, you burn it down and rotate. If livestock contracts viruses, you sacrifice the herd and begin again with fresh stock. Neither applicable to humans.


>>> how do i know that they have reached a holding plateau - is this> when you start, they improve and then regress but then get to a> point where they just keep improving?

This is why I say the cake is not fully baked yet... :)

Just try to eye-ball it by observation. The holding plateau isn't when you start (although if they just started a med or supplement, you need to allow some time for the person to adjust to that first so any improvements or negatives are not confused. And you would know which item to increase or reduce).

==================
The general plan is as follows.
Start at 1-2 capsules of the ViraStop between meals per day. Increase as tolerated. If you get to a point where the person becomes 'negative' (agitated, fussy, rash appearing, etc). hold at that dose for a couple days. This is similar to the low-and-slow approach in starting enzymes for food digestion and yeast die-off. What we see is the after a few days, the person adjusts and the negatives go away. Then increase another capsule per day.

At some point, the negatives stop happening even as you increase the enzymes (ViraStop) capsules much more. That is considered the Holding Point or plateau. You can try really increasing the enzymes more, but if you don't see additional improvement, not need to go through more capsules.

Keep dosing at the Holding Point for about 3 weeks. Then start reducing the number of capsules per day. The improvements should 'stick' and maintain. If at any time in the reducing phase, the person starts to regress, increase the number of capsules back up a little (1-2 usually works). Then keep at THAT dose for 1 more week.

At the end of a week, see if you can reduce the enzymes again.
==================

Viruses have a totally different type of reproduction and infection cycle than bacteria, yeast, or parasites. Viruses manifest in a cycle nature, rather than linear or exponential. So the dosing treatment is different as it follows or reacts to the virus.

Viruses are only vaguely understood. Science doesn't know why a flare-up might happen or what causes it to shut-down (like why do people get herpes flare-ups and what cause shingles to suddenly appear). It probably varies by person.


>>>> and how long do people use virastop for? sorry its just i noticed on another post on a different site that they had been using for at least 10 weeks but didnt say how long they had used it for.

It depends on how the cycle works out for you. Some take longer to get to the holding point and some get up to that point in the first week. Then on the reducing capsule point, same thing. In our trial runs, I am suggesting a 1-2 month timeframe, but if someone wants or needs to go longer, they can. The holding point is 3 weeks in itself. Taking 10 weeks would be roughly in line with that.

Remember that this is still being tested and worked out. If your doctor or other esteemed expert person reads this and says they think it is total poppycock, that's fine. Everyone has their opinion. All of this effort is just to try to provide some guidelines and options for those who don't have any, and other things aren't working. It is not taking anything away from someone who already has a solution.

I think it is important to know what you are getting into. That's why these trials are being done. To sift a few things out. I really, REALLY want to thank everyone that participated or contributed information to help with this effort.

Enzymedica is donating the enzymes per a request (extremely generous on their part...there was an equal possibility it wouldn't work at all). Everything else is totally volunteer on everyone's part. I have no vested interested personally in how this turns out (which is a really good thing).

The average dosing of capsules per day between meals of ViraStop (the therapeutic dose) is between 12-20 capsules with 12 being the miminum. If you need to go to 25, that's fine too. It is a lot but not for a therapeutic use of enzymes. Other areas of therapeutic enzyme use are commonly given at 45-90 a day. But is isn't forever...shorter term.

Some people are seeing no improvement or reaction until they hit that therapeutic dose. Then it happenes. Others see it at 2-4 capsules a day (immediately). Just so you know. Please note that the general program is just that...nothing specific, but rather the pattern to look for as the enzymes are increased to the 'holding plateau' dose. It is the pattern that is more important than specific numbers of capsules taken at specific
times.

One of the symptoms of virus problems appear to be a cycle pattern of spontaneous regression followed by sponteneous improvements. Drives the parent batty trying to figure out what is going on. The time intervals may cycle in weeks, or months, maybe even years (if people get that old). This patterning was reported occassionally several years ago and that got me interested in what it might be (inquiring minds what to know,
<smile>).

This viral therapy is not one of those things you do for life. It is a much shorter-term 'treatment' you do and then wrap-up. At the moment, the results are looking real good, but it is not quite ready for prime-time. As more information develops, I will add it to this page.



Anti-virals and Yeast Increase

It has become apparent that yeast MAY increase with ANY antiviral program that is actually working. It doesn't happen with everyone doing an antiviral or everyone with yeast. But it can happen. Usually good benefits are see at the same time as the yeast increase. This is reported with Virastop, Valtrex, acyclovir, olive leaf extract, and Lauricidin (a coconut oil product). This weekend I talked with a guy that now works with Enzymedica who used to work with some candida researchers. We talked about this and he suggested that it might have something to do with the carbohydrate component on the envelope of certain viruses.

Viruses consist of proteins at the core. Some viruses are covered in a layer (envelope) made of lipids (fats) with glycoproteins interspersed in the layer. These 'spikes' stick out from the virus. The spikes connect with the surface of cells and are integral in the infection process. Viruses with this layer are called enveloped viruses and the others without this layer are called non-enveloped viruses. There are lots of images on the internet showing this...here is one http://asm.wku.edu/pix/cells/virus.gif

The idea is that if the virus is being destroyed or unable to connect to the cell, you would have these carb (sugar) components out floating around which may end up as yeast food. This would appear as an antiviral working with some yeast increase due to extra carb entities being available during the virus cycle breakdown. Please understand this is only a hypothesis based on science compared with people's experience with various products. It's a possible, logical explanation but it doesn't mean that is actually what is happening. I did go looking to see how this might hold up.

ViraStop does not contain carb enzymes, only several types of proteases. If the ViraStop were breaking down the protein proportion, then that would leave the carb portion, possibly for yeast. Perhaps taking a carb enzyme with the ViraStop if yeast is a problem would help??? Candex, No-Fenol and Candidase are all carb containing enzymes...although there are other straight carb enzyme products such as V-Gest, Zyme Prime, or any broad-spectrum product. Interesting that a couple of people used Candex with the ViraStop to help with the yeast issue. The carb enzyme *might* be helping with the carb portion in addition to helping directly on yeast. I checked the Lauricidin site for info. Lauricidin is a type of oil or fat. Now, on the Lauricidin site it says:

Q: Your web site describes Lauricidin® as being able to inactivate "enveloped viruses" such as measles. Does Lauricidin® eradicate the live measles virus when it is found in the intestinal tract? If so, do you know if there is a change in patients' symptoms as a result?

A: Lauricidin® has been shown to reduce viral loads of envelope viruses as well as other bacterial and yeast organisms. The negative symptoms from the virus seem to be reduced or eliminated.

Interesting it specifically says 'enveloped viruses' and not all viruses. The site also says:

'The antiviral action attributed to monolaurin is that of fluidizing the lipids and phospholipids in the envelope of the virus, causing the disintegration of the microbial membrane.'

If the Lauricidin is disintegrating the fatty lipid envelope, that would leave the glycoprotein components left...possibly ending up as yeast food. Moving along to check on this idea with Valtrex, Valtrex works by inhibiting viral DNA replication, apparently within the cell: http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=2185

Valtrex blocks virus replication but the viruses present would still need to be cleared out...not sure how that fits the glycoprotein idea (need more information). What I did notice is that Valtrex is given for enveloped viruses.

1. It might be that some people see yeast increase because they deal with enveloped viruses while others do not because they have non- enveloped viruses.

2. The difference in people's experiences may also be that if you have enveloped viruses and have enough enzymes to deal with the glycoproteins, you won't have yeast increase.

3. Another possibility is that the yeast you have isn't physically located in the body so that it can take advantage of any loose carb components floating around.

Maybe the differences are due in part to some of each of these. So how do you know if the virus you deal with is enveloped or non- enveloped? Here is one list I found:

Virus Groups by Type

DNA Enveloped Viruses:

  • Herpes Simplex Virus Type 1 (herpes labialis)
  • Herpes Simplex Virus Type 2 (herpes genitalis)
  • Hepatitis B virus Smallpox Virus +

RNA Enveloped Viruses:

  • Influenza Virus
  • Measles Virus
  • Mumps Virus
  • Rubella Virus
  • Parainfluenza Virus ( Bronchiolitis in infants, croup in young children, common cold in adults)
  • Rabies Virus
  • HIV
  • Hepatitis C Virus
  • Respiratory Syncytial virus
  • Hepatitis D virus
  • Ebola/Marburg ( filovirus family) h.f. viruses
  • Lassa Fever Virus (arenavirus family) h.f
  • Coronaviruses
  • Hantaviruse {(Hantavirus Pulmonary Syndrome (1993 in the Western US: influenza like symptoms + respiratory failure due to inhalation of aerosols of the rodent's urine and feces)}
  • Japanese encephalitis virus

DNA Non-enveloped Viruses:

  • Parvovirus B19

RNA Non-enveloped Viruses:

  • Poliovirus
  • Coxsackie viruses
  • Hepatitis A Virus
  • Reoviruses
  • Astroviruses

Source http://eies.njit.edu/~ellerbus/download/EMERGDIS.doc
====================

I got better results when searching when I used the term 'glycoprotein' rather then carbohydrate or sugar with viruses. This page will be updated as more information is found.

Lysine and Viruses

Lysine is thought to help with viruses, although there is very mixed information out on whether this is true or not. Some of the following reasons may point to why there is a conflict. Lysine is a needed amino acid. Investigate shows that lysine is thought to be helpful for the *herpes simplex virus*...not all viruses. Some research studies show it might be helpful with herpes where other studies show it might not.

How lysine works on viruses is by inhibiting another amino acid that viruses require for protein reproduction. The herpes simplex virus needs the amino acid arginine for a critical step in the production of its protein. Lysine and arginine compete for the same spot somewhere along the line. When arginine is in higher supply than lysine (as available in the location of the virus), this promotes viral replication and 'growth.' When lysine is in greater supply than arginine, viral replication is inhibited. So taking lysine may be helpful in herpes simplex control IF the ratio of lysine to arginine favors lysine, in the location of the virus. Even if you are taking lysine, if the quantity is not greater than the quantity of arginine, you may not see any benefit with the lysine. The lysine may be working but not in high enough quantity in the location where the virus is. If lysine is helping with a herper virus, the pathway is indirect not directly acting on the virus. Lysine is higher in meats, fish, and dairy foods.

Here are some links on lysine: http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/lly_0166.shtml

http://www.wholehealthmd.com/refshelf/substances_view/0,1525,862,00.html

Olive Leaf Extract and Viruses

I was trying to look up the mode of action of OLE, that is, how does it fight viruses exactly. We found some on lysine action on herpes virus (other viruses aren't indicated, only herpes). And also on enzymes such as in ViraStop. And also Valtrex. With OLE, I found some info suggesting it helped in a variety of ways. Here is the closest to how it acts..."olive leaf extract is a natural reverse transcriptase inhibitor." (except on OLE from LifeExtension article on viruses at bottom)

Well joy of joys...what does that mean? This site explains what a reverse transcriptase inhibitor is: http://www.aidsmap.com/en/docs/A2D0130F-BC91-49B9-945C- D426AFC229D2.asp

"The use of reverse transcriptase is a unique characteristic of retroviruses such as HIV. After HIV has attached itself to a human cell and released its genetic material in the form of RNA into the cell, reverse transcriptase converts the viral RNA into a piece of DNA using the 'nucleotide' building blocks in the cell. This process is known as reverse transcription."

Basically, it seems to say that this is a feature of retroviruses. Perhaps olive leaf extract is most effective on the category of viruses known as retroviruses. Also, notice that the olive leaf extract is inhibiting the process of the virus taking over the cell's DNA. It is saying that an enzyme known as 'reverse transcriptase' is produced by the virus and helps the virus take over the cell's DNA. Olive leaf extract stops this process of the virus destroying the cell and also reproducing.

It's important to note that in reading articles on viruses, the term 'protease inhibitor' is used often.In this example of olive leaf extract, the OLE is a protease inhibitor...that is, it is inhibiting the protease made by the VIRUS. It does not mean it is inhibiting proteases we take as supplements or our own naturally produced proteases. Proteases and protease inhibitors are very very specific. So if you are taking ViraStop, Vitalzym or some other protease based enzyme supplement, the OLE is not inhibiting those proteases. This information also appears to support why taking OLE and ViraStop together works if each are working on different aspects of the viral lifecycle.

==========================
Full article at site:www.lef.org/protocols/prtcls-txt/t-prtcl-059.html
==========================

Olive Leaf Extract Olive leaf extract is a nonprescription, over-the-counter food supplement that has been used as a natural treatment of viral, bacterial, fungal, and parasitic infections; skin diseases; arthritis; heart disease; and many other illnesses. The ethnopharmacology of the olive tree has a colorful historical past because it has been thought to be the tree that is referred to as the "Tree of Life" in the Book of Genesis. The ancient Egyptians may have been the first to employ the olive leaf as part of the mummification of their royalty. Hippocrates, the father of medicine, used olive oil to treat ulcers, cholera, and muscle pains more than 2500 years ago.

In later cultures, olive oil was used as a popular folk remedy for the treatment of fevers. In the 1850s, the first formal medical documentation of the use of olive leaves to treat severe cases of fever and malaria was made. In 1854, a healing remedy of olive leaves was published in Pharmaceutical Journal, England's leading medical journal of that time. Italian researchers also discovered that olive leaf extract could lower blood pressure in animals.

It was also confirmed that olive leaf extract increased blood flow to the coronary arteries, relieved arrhythmias, and treated intestinal muscle spasms. In addition, olive leaf extract is thought to have powerful antioxidant properties. Countless studies illustrate that antioxidant activity is crucial to the management of HIV disease.

Olive leaf extract contains a phenolic glucoside, known as oleuropein, which has been shown to be the source of its extremely powerful disease-resistant properties (Renis 1970; Hirschman 1972; Fredrickson 1994; Privitera 1996; Ripka et al. 1996; Gay Men's Health Crisis 1997-1998; Walker 1997). In the late 1960s, olive leaf extract was tested by Upjohn Pharmaceuticals and was found to kill a large number of viruses. According to Jim Van Sweden at Upjohn Pharmaceuticals, Dr. H. E. Renis conducted prolific research on olive leaf extract, working in Upjohn's Department of Virology. His study, "In Vitro Antiviral Activity of Calcium Elenolate," published in the peer-reviewed journal Antimicrobial Agents and Chemotherapy, revealed calcium elenolate's formidable antiviral activity because it inactivated almost all viruses tested against it (Renis 1970).

Calcium elenolate is a chemical compound of oleuropein found in olive leaves. William Fredrickson, Ph.D. (researcher and CEO of F+S BioGenesis Group, Inc.), has also studied olive leaf extract extensively and believes the compound (+)-2-epienolic acid found in olive leaf extract is a natural reverse transcriptase inhibitor. He cites Hirschman's (1972) study, "Inactivation of DNA Polymerases of Murine Leukemia Viruses by Calcium Elenolate," as documentation of olive leaf extract's reverse transcriptase mechanism of action. He also believes that it is a natural protease inhibitor because he has seen 100% protease inhibition activity in vitro while conducting a laboratory screen of oleuropein. However, there is no documentation to support his observation. In 1996, as an alternative to taking toxic pharmaceutical protease inhibitors, the AIDS community discovered this possible natural source of protease inhibitors known as olive leaf extract. It has been shown to be nontoxic in all animal studies, even when given in doses of 3 grams per kilogram of body weight.

By functioning as a reverse transcriptase inhibitor and a believed protease inhibitor, it is selectively cytotoxic to virus- infected cells but has never shown any toxicity to human DNA alpha-, beta-, or gamma-polymerases. Olive leaf extract has been taken by persons with AIDS in doses of one 500-mg capsule or tablet 4 times perday. Olive leaf extract products should have the recommended 23% oleuropein content and be guaranteed fresh. Olive leaf extract does not have any side effects per se, although some people may experience a "die-off " effect (also called the Herxheimer reaction). A "die-off " effect is caused by a rapid increase in volume of waste material and pathogens being brought into the lymph system. Reactions to the die-off effect include extreme fatigue, diarrhea, headaches, muscle and joint achiness, and flu-like symptoms. These reactions are temporary and will pass once the body has expelled the circulating toxins. If these detoxifying symptoms are too uncomfortable, reduce the amount of olive leaf extract taken or discontinue using it temporarily. Upon feeling better, resume the supplement at a lower amount and increase it to your desired dose slowly.

 

 

 

 

 

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