Off GFCF Diet with Enzymes
last updated 8.25.05

The following are some of the many success stories from people who have gone off a casein-free, gluten-free diet (and many times other food-free diet) with DPP IV containing enzyme products. At this time many people have been off the diet for nearly 2 years or more, and only report more gains as they continue on enzymes. Medical practitioners have very different views on this depending on their training, and business and professional affiliations, it is good to consult with your health practitioner whenever making any medical decision, including going on restrictive diets or using anything other than a standard dose of supplements. It is up to each individual family to decide what is the most appropriate amount of food elimination and enzymes for them, but if you are wondering if it is at all possible, the answer is "YES, many have done this successfully."

From Kristin:
My 8yr old daughter has been off the gfcf diet for a couple of weeks now and just keeps doing better and better!! Her language skills are improving daily-so much more spontaneous speech(we were at the dr's for a sinus infection a couple of days ago and I was walking ahead of her in the hall and she yelled"Wait for me!" Such a great thing!) She has gained weight(finally hit 50 lbs after staying at 45 for quite awhile.) She is doing great in school-her new report card has her knowing 68 out of 77 spelling words for the marking period-she is reading everything-I can hardly keep up with her when we are out shopping because she is reading me everything she sees. Much more interaction with her baby brother. She can tell me when she doesn't feel well what is wrong-she had a headache from this sinus infection and told me...she also said "it hurts"-she just didn't do this before. I am soooo excited!! Having her eating "real" food again is also just wonderful-nice to have the option of a "reward" ice cream cone again lol. Her lunchbox comes home cleaned out instead of 90% full these days and tomorrow she gets to enjoy a birthday cupcake the same as everyone else in her class and she is buying her lunch at school(pizza day.) This is like a dream come true for her Dad and me.

From Leslie:
Hi group
My son continues to do very well in his program - I have started working and can't spend as much time with this group as I would like! Thought I would update you on his progress - six months on enzymes and return to normal diet (10 months GFCF diet prior to this) Although he would like to live on peanut butter sandwiches lately!! (his grandma says dad was the same way!!)

After seven months of home based ABA, his team has decided it is time to reduce the number of hours spent at home at the table, and get out into the community on many field trips for more natural teaching environments and to work on considerable social deficits. He is flying through the programs at the table, and needs to practice these skills in a more natural environment now. He is amazing his ABA teacher consultant who designs his IEP for preschool - he meets all the goals within a month and she has to do a new one up! His speech is coming in, slower than I would like and with terrible (but improving ) pronounciation, but he can use three and four word phrases now. His turn taking and imaginative play are awesome with therapists. Follows around and horses around with his older sister like a normal three year old. LOVES to have books read to him. Knows the words to many of them. Knows how to sight read many words – knows alphabet (upper and lower), can count to 29 . Loves music therapy (used to hate music - especially if sung to him) Will help shop for groceries, filling the cart, empties it to the cashier, and will help carry bags to the car (used to just run around and scream in the store)

Sensory issues are MUCH reduced - can tolerate messy hands/feet in the wet sand (will actually dig in with his fingers happily), swimming in a pool, having a mucky face etc (used to freak out with tactile sensations) The list goes on and on. Almost always happy - screaming problems (when frustrated) are almost gone. Stims are still present (verbal ones are increasing, but we were warned this might happen as he gets more speech), but we are able to redirect him fairly easily. Poops are MUCH better since the Colustrum was added (although the enzymes helped him with getting rid of the undigested food in there, they were still always too soft and runny) Overall, we are thrilled with Nick's progress to date - we have a long way to go, but we seem to be on the path!

From Pam:
just have to tell you all that everyday we have been adding "stuff" back into my son's diet. Like saltines with soup (an old favorite) bologna and whole wheat bread with mayo!!! HE is really happy! And with the addition of the no- fenol (getting graphic here so watch out) his bowl movements have really firmed up. (No more hanger's on as my son put it!) that is a big improvement for him. So once again Devin thanks for the big and little favors. I am still trying to regulate how many of each enzyme he needs and keep erring on the side of too many just to be on the safe side. I will let you know how he keeps doing good or bad but so far only positive things.

More from Pam:
Well friends it looks like the diet is a thing of the past for us. It started with that piece of pizza a couple of weeks back and that pizza led to another and than last night for my daughters birthday we gave our son more pizza and ice cream cake and he is great! This morning I gave him gf waffles that had soy in them (my son could not have soy) and then for lunch we just went whole hog and went to burger king. HE LOVED IT! He said again what he told me after the first pizza treat. "the reason I am so crabby all the time is cause I dont get to eat what I want". Well for those of you who know my son's behavior "issues" I need not explain, but for those of you who don't I will let you know that he can be EXTREMELY oppositional and defiant, yelling at me when he does not get his way and VERY obsessive compulsive. I told him that if I had known that letting him eat "regular" food would have made him (shall we politely say) LESS CRABBY I would have done it A LONG TIME AGO!! LOL I really feel though that being gf/cf/soy free for almost a year and on Devins enzymes for 6 months, I now have the courage to do this. (so much for being conservative) We are all feeling like we have gotten a missing part of our life back. My daughter said it was much more fun eating chicken nuggets and fries when you can eat it with your little brother! I will keep you all posted!

From Leah:
a little back ground for those that don't know me.... david was 9 in june. which is also when we went gfcf.... had some progress but nothing major or fast.... went on houston's enzymes on halloween... 3 days later david had a real sense of humor!!! soon after he began reading.... went from 1st grade 1 sem to 2nd grade in 1 mo!! he began to do his chores and to try wriggle out of them too!!! interaction with his family and friends!!!! lots and lots more stuff too...

he seems to have settled in to a routine now... of a little regression just like an infant ant the a gain of some sort.... letter sounds have finally started to click as verbs both regular and irregular... he is not perfect with them but darn close!! his tap danceing is really coming along!! He hounds me about things in a normal kid way and dresses the dog in clothes!!!! let me explain.....

the other day david was in the back yard playing with the dogs as he always does now... we have a bassett hound that is his...(perfect dog for a companion VERY patient VERY sleepy) the neighbor was getting a new roof so there were roofers looking down upon our yard....hubby came home and nearly fell down laughing.... david was playing soccer and poor george was the other team....uniform and all!!! he had put a shirt on him and then somehow put a pair of shorts on him!!! now this is no small feat as poor george weighs in at about 55lbs!!! the roofers had been watching to see what would happen when georgie had to use the bathroom!!! OH AND he was dressed in bright yellow!!! shirt and shorts!!! i think he tried to put soccer shoes on him too as they were also in the back yard!! poor george now sports all sorts of things from binoculars to action man strapped to his back!!

davids gains are not in a real measurable way as in number ans such but as in age approiate things... still not age appropraite how ever much better that before!! yahooooo!!!!

we have now decided to go completely off of the gf/cf diet as we have daily infractions anyway...seems that we are still getting gains so ............... may as well stop kidding our selves and stick with what works for us... i know that many of you feel that this is bad but there seems to be no problem for us. so please don't flame me...devin houston's enzymes have made our lives sooooooooooooooo much better an real quality of life that was not there before.... thank you Dr. Houston!!

From Susan:
Congratulations Leah!!!! No flaming here-we chucked the diet at the very first opportunity lol!!! I intended to start out adding foods slowly-but it worked so well my daughter has gluten and casein several times a day now. Its just wonderful!! Its such a nice thing to just see her eat and enjoy it again. Loved your dog stories-my sister and I did that to our dauschaund when we were kids lol. I'm so happy for you and your son!!! These enzymes are just amazing.

From Cindy:
My son is 8 ½ years old, diagnosed with Asperger's Syndrome and started taking the Peptizyde and HN-Zyme Prime enzymes from Houston Nutraceuticals one year ago on April 21, 2001. The short version is, the gfcfsf diet helped, the enzymes helped more, being off the diet and on enzymes helped the most. The long version follows.

Before starting the Houston enzymes, my son had been gluten-free, casein-free, soy-free, corn-free, egg-free and off of numerous other foods over the course of the previous year. The diet helped my son with many areas of development.

At two weeks after starting the enzymes, his teacher and speech therapist observed an increase in awareness, class participation and humor. At four weeks, the teacher called me to report a large increase in problem-solving skills, improved socialization, an increased enthusiasm for learning and generally a happier temperament. During this time, we had gradually expanded our son's diet to include some of the previously banned foods including gluten and casein. The teacher said, "It's like something out of the movie 'Awakenings'" I was familiar with the movie based on Dr. Oliver Sacks patients who come out of a catatonic state due to a new medication. I remembered how their awakening did not last, though, and I was afraid my own son's awakening would not either.

A few weeks later, our son was off the diet and doing better than ever. The following areas showed steady improvement over the next weeks and months while on the enzymes and off the diet: eye contact, sound tolerance, initiating conversation, obsessiveness, affection, empathy, self-stimulatory behavior, self-injurious behavior, transitioning, desire for physical activity, skin color, adherence to routine, stools, interaction with brother, waking up, awareness, problem solving, short-term memory, humor, vocal pitch, natural rise and fall of speech, rate of speech, disposition. At six months on enzymes and still off the diet, I went through all the evaluation deficits from testing a year before which qualified my son as meeting the educational criteria for Asperger's Syndrome. Out of 58 weaknesses, the teacher and speech therapist responded that only 2 were still an area of concern, 10 were now only a mild concern, and on 2 they didn't know if there was a change or not. So 54 out of 58 prior weaknesses were either no longer a concern or were only a mild concern.

Since starting the No-Fenol two weeks ago, he seems even happier, more affectionate, is eating more, and is better able to tolerate some phenolic foods, particulary artificial colorings. I do not notice a decrease in stimming with the No-Fenol. My son's stims can be distracting at home, but are not observed at school.

Last week I asked the speech therapist if all improvements since enzymes have been maintained. She said the improvements were still present and her only concern was sometimes our son is quiet and appears on occasion not to be listening, but always is and knows the answers to questions. She said he is the only student that notices when their class is in the hall lining up for lunch, yet this doesn't interfere with his attention to the task at hand. She said he does not initiate a lot of conversation, but will do it when asked and participates appropriately. She said he looks out for the group and encourages them to follow directions. She has no big concerns about his vocal pitch, although it gets high when he is excited. It is more of a concern to me than to her, but I think he controls it better at school and the speech therapist and I both agree it is so much better than it was that it is best left alone for now. She said his pragmatic language (social language) is appropriate now; his problem solving and common sense is "perfect". He has a few articulation errors, but has maintained the improvements with the previous numerous errors.

I asked the classroom teacher the same question a few days ago and she agreed that all progress is still present and he is doing well. She said he is quiet, and at times seems to not be paying attention, but always is because he answers all questions correctly. She told me on several occasions throughout the school year that he is "doing great". At his school Valentine's Party, she shared with me that he is liked by the students and fits in well. Last November, when it was apparent that the enzymes were responsible for so many changes, I asked her if she would describe my son as someone having any characteristics of Asperger's or autism. Her answer was, "No."

I observed on a field trip last week that the other students seem to like my son and his interaction with them was excellent. At one point when the class was running up a hill, I saw him shake and twist his hands for a few seconds on two occasions, but otherwise, he appeared "typical". When he runs, he sometimes stims like this, but no one seems to be bothered by it. My son has continued to interact with his brother since starting the enzymes. Before enzymes, I would force him to tell his brother "Goodbye" in the morning, but now he does so willingly and they often tell each other, "Goodbye, I love you forever!" Before enzymes, he tolerated his brother for very short spurts of time and otherwise yelled at him to "Go away, baby!" They usually sleep apart each in their own rooms, but after starting enzymes, beg to sleep together on weekends to have what we call, "Brother Slumber Party". Recently, I've given in more and let them sleep together during the week, too, although then they stay up too late. They fight now, too, but they are acting like brothers which is something I had given up on ever seeing before starting the enzymes. Before the enzymes, my youngest son would ask, "Why does my brother hate me?" The youngest does not ask that any more.

The year we did the diet was difficult. My son was high functioning and not very happy about altering his diet. In fact, he would ask, "Why are you doing this to me? Why can't I just eat regular foods?" I kept removing foods and he kept developing sensitivities. The diet helped him function better, so I knew I had to do whatever it took to keep going. The keeping going part was getting treacherous, though. It seemed running out of "safe" foods was a possibility.

Trying to produce foods that matched what was being served the next day for birthday treats, classroom food rewards, and student council doughnut sales was all-consuming. I was either cooking, cleaning up from cooking, planning the next meal or treat, researching safe foods and recipes on the internet, or driving around town to buy special foods. Over time, my son could not tolerate anything made from a mix, so everything was from scratch. I finally asked the teacher to send a note to all parents requesting a day's notice on any treats they would bring to school. Many nights I would be up late trying to duplicate the goodies from a description given to me by a parent a few hours earlier on the phone. I finally learned the easiest way to handle my son's distress over his treat never looking exactly like the others was to make a large batch for the whole class. So I was often making large batches of cookies, doughnuts or cupcakes, not to mention lunchbox foods, breakfast foods and dinners. Sometimes I would pay my son money to make up for things not being exactly fair or would offer to pick him up early from school so he could have extra TV time at home while the other kids ate special treats at the end of the schoolday.

Everything got better with the enzymes and it got better fast. My son was eating "regular" foods, we no longer battled over the diet, I was free to leave the kitchen, we got to eat at restaurants and relatives' homes, and my son transformed into someone happier, healthier, and more connected to his world. My son still has somewhat of an awkward gait at times, he sometimes stims at home or at unstructured activities, he still prefers not to talk about social situations although he handles them well, some days the eye contact is less than others, he talks a little slow at times and his voice gets too high when he is excited, but he is overall functioning very well and is perceived by others as "typical". He is concerned about what others think and feel and wants to fit in and indeed he does fit in.

His own summary of the enzymes today: "I think the enzymes help me a lot because when I was 6 or 7 ½ I felt like a different type of normal and then when I took the enzymes I felt like I just saw a great movie or got a great new toy. When I didn't take the enzymes I couldn't eat other kinds of foods but when I took the enzymes I could eat other foods and I felt so happy that I didn't have to worry about any other thing again." Thank you.

From Eddie:
It was just by chance that although I had my Lactose Intolerance in control through choosing carefully what I eat (and also taking P+ tabs just occasionally for safety, together with treating my milk with Lactase Enzyme), I scarily sometimes had the dreaded symptoms without my knowing why. The answer came when I made an appointnment to see a Consultant about the Lactose Intolerance. At the closing of the interview, he just "threw in" a remark - By the way your blood samples tell me that you should also keep an eye on your gluten intake because you have the beginning of gluten intolerance. So suddenly I realised that the occasional 'blips' to my symptoms were probably due to gluten.

Since then I have begun to also take Glutenzyme caps from Mario and the results have been very good.

I recently had an example which confirmed to me that I am now definitely GI. It was a few days ago when I ran out of the caps and within 48 hours I experienced the dreaded symptoms once again! You see, I also eat with great enjoyment the Rock Buns which my wife makes from non gluten-free flour and on the said occasion I had forgotten that I had run out of the caps. Needless to say, I now have the caps in my possession!

Note: GlutenZyme is sold by a UK company Biocore and has been out several years with good success replacing a GFCF diet.

Research supporting enzymes for gluten and casein breakdown

Characterization of the prolyl dipeptidyl peptidase gene (dppIV) from the koji mold Aspergillus oryzae.

Doumas A, van den Broek P, Affolter M, Monod M. Nestle Research Center, 1000 Lausanne 26, Switzerland. PMID: 9835566 [PubMed - indexed for MEDLINE]

The koji mold Aspergillus oryzae secretes a prolyl dipeptidyl peptidase (DPPIV) when the fungus is cultivated in a medium containing wheat gluten as the sole nitrogen and carbon source (MMWG). We cloned and sequenced the DPPIV gene from an A. oryzae library by using the A. fumigatus dppIV gene as a probe. Reverse transcriptase PCR experiments showed that the A. oryzae dppIV gene consists of two exons, the first of which is only 6 bp long. The gene encodes an 87.2-kDa polypeptide chain which is secreted into the medium as a 95-kDa glycoprotein. Introduction of this gene into A. oryzae leads to overexpression of prolyl dipeptidyl peptidase activity, while disruption of the gene abolishes all prolyl dipeptidyl peptidase activity in MMWG. The dppIV null mutants did not exhibit any change in phenotype other than the absence of prolyl dipeptidyl peptidase activity, suggesting that this activity is not essential. This loss of activity diminished the number of dipeptides and increased the number of larger peptides present in the MMWG culture broth. These effects were reversed by the addition of purified, recombinant DPPIV from the methylotrophic yeast expression vector Pichia pastoris. Our results suggest that the DPPIV enzyme may be of importance in industrial hydrolysis of what gluten-based substrates, which are rich in Pro residues.



General Strategies
Feingold / Failsafe
Casein-free / gluten-free
Yeast Control
Specific Carbohydrate
High-protein / low-carb

Off GFCF Diet w/ Peptizyde
Enzymes - No Crashing


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